Advanced care for lasting vitality.
Experience therapeutic plasma exchange through trusted clinics. Feel, think, and live better, longer.
Science-backed longevity care. Expert-led. Patient-centered.
What Is Therapeutic Plasma Exchange (TPE)?
Your blood carries more than oxygen and nutrients. It carries signals—proteins, antibodies, and byproducts that influence how your body functions, recovers, and ages. Over time, some of these can build up faster than your body clears them. Therapeutic Plasma Exchange, or TPE, separates and replaces your plasma, helping reduce that burden and creating a cleaner environment for your body to work from.
As Seen In
Is TPE right for you?
Explore the benefits of therapeutic plasma exchange. By reducing inflammatory and age-related factors in your blood, TPE may help create more favorable conditions for your body to recover, repair, and perform at its best.
- Reduce chronic inflammation linked to fatigue, pain, and cognitive fog
- Boost mental clarity, memory, and cognitive function
- Support healthy circulation and immune balance
- Enhance recovery and performance
- Promote long-term vitality and resilience
Built on decades of science. Setting a new standard of care.
Therapeutic Plasma Exchange has been used in medical practice for over 50 years and is recognized by the American Society for Apheresis for conditions affecting the immune, neurological, and metabolic systems.
Circulate Health is building on that foundation. Our clinical trial, published in Aging Cell, showed an average 2.6-year reduction in biological age after just six TPE sessions. We’re advancing the science of longevity through standardized protocols, outcomes tracking, and ongoing research.
Elevate your practice with Circulate Health
Circulate partners with clinics to deliver therapeutic plasma exchange as a turnkey, fully supported clinical service. We handle the complexity so you don’t have to:
- Expert apheresis nurses, fully staffed and trained
- FDA-cleared equipment and standardized protocols
- Quality assurance, supply management, and ongoing support
- Marketing and Customer Success Support
Trusted by clinics and partners
Washington
New York
California
Colorado
Florida
Texas
Utah
Georgia
Illinois
“Watching all my bloodwork numbers move into or towards the green gives me a lot of confidence in what I’m doing with TPE”
– Patient
“Circulate’s TPE program expanded our clinical capabilities, elevated patient care, and differentiated our practice—without adding complexity.”
– Tringali Clinic
Common questions about TPE
What is Therapeutic Plasma Exchange?
Your blood carries more than oxygen and nutrients. It carries signals—proteins, antibodies, and byproducts that influence how your body functions, recovers, and ages. Over time, some of these can build up faster than your body clears them. Therapeutic Plasma Exchange, or TPE, separates and replaces your plasma, helping reduce that burden and creating a cleaner environment for your body to work from.
Is TPE safe?
Yes. TPE has been used safely in hospitals and specialty clinics for over 50 years. Most patients experience no complications. Mild effects like temporary lightheadedness due to mild drops in blood pressure, tingling sensations or cold sensation, mild stomach upset, or fatigue can occur and typically resolve quickly. Each treatment is continuously monitored by a trained apheresis nurse to ensure comfort and safety.
What are the clinical indications for TPE?
TPE is an established therapy across a range of conditions, including:
- Autoimmune disorders
- Metabolic and hematologic disorders
- Neurological and renal disorders
- Longevity and prevention medicine
- Providers should evaluate the evidence base and clinical appropriateness for each indication.
What should providers consider before prescribing TPE?
Comprehensive evaluation: Review the patient’s underlying diagnosis, consideration of comorbidities, goals of care, and contraindications.
Medication management: Certain medications (e.g., immunosuppressants, biologics, blood pressure medications, and blood thinners) may require timing adjustments around treatment sessions.
Baseline labs: Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), coagulation profile, and relevant disease-specific markers should be reviewed prior to initiation.
Hydration and vascular access: Adequate venous access and pre-procedure hydration are key for optimal outcomes.
What kind of outcomes can be expected?
Patients frequently report measurable improvements in energy, cognitive clarity, and overall vitality. Objective data may include reduced inflammatory biomarkers, improved immune balance, and better metabolic parameters. Early studies suggest potential benefits for supporting healthy aging and extending healthspan through improved biological function.
Additional benefits include:
- Help minimize inflammation to mitigate biological aging
- Boost mental clarity, improve memory, and enhance cognitive function
- Promote heart health and improve circulation
- Assist in the removal of toxins and support the body's natural detoxification process
- Strengthen the immune system to feel well and stay well
- Revitalize and restore overall health and wellness
- Support healthy lipid levels by removing harmful cholesterol
