Advanced care for lasting vitality.
Experience therapeutic plasma exchange through trusted clinics. Feel, think, and live better, longer.
Science-backed longevity care. Expert-led. Patient-centered.
What Is Therapeutic Plasma Exchange (TPE)?
Your blood carries more than oxygen and nutrients. It carries signals—proteins, antibodies, and byproducts that influence how your body functions, recovers, and ages. Over time, some of these can build up faster than your body clears them. Therapeutic Plasma Exchange, or TPE, separates and replaces your plasma, helping reduce that burden and creating a cleaner environment for your body to work from.
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Is TPE right for you?
Explore the benefits of therapeutic plasma exchange. By reducing inflammatory and age-related factors in your blood, TPE may help create more favorable conditions for your body to recover, repair, and perform at its best.
- Reduce chronic inflammation linked to fatigue, pain, and cognitive fog
- Boost mental clarity, memory, and cognitive function
- Support healthy circulation and immune balance
- Enhance recovery and performance
- Promote long-term vitality and resilience
Built on decades of science. Setting a new standard of care.
Therapeutic Plasma Exchange has been used in medical practice for over 50 years and is recognized by the American Society for Apheresis for conditions affecting the immune, neurological, and metabolic systems.
Circulate Health is building on that foundation. Our clinical trial, published in Aging Cell, showed an average 2.6-year reduction in biological age after just six TPE sessions. We’re advancing the science of longevity through standardized protocols, outcomes tracking, and ongoing research.
Elevate your practice with Circulate Health
Circulate partners with clinics to deliver therapeutic plasma exchange as a turnkey, fully supported clinical service. We handle the complexity so you don’t have to:
- Expert apheresis nurses, fully staffed and trained
- FDA-cleared equipment and standardized protocols
- Quality assurance, supply management, and ongoing support
- Marketing and Customer Success Support
Trusted by clinics and partners
Washington
New York
California
Colorado
Florida
Texas
Utah
Georgia
Illinois
“Watching all my bloodwork numbers move into or towards the green gives me a lot of confidence in what I’m doing with TPE”
– Patient
“Circulate’s TPE program expanded our clinical capabilities, elevated patient care, and differentiated our practice—without adding complexity.”
– Tringali Clinic
Common questions about TPE
What does my result mean?
Your result reflects the quantity of microplastics detected in your bloodstream at the time of testing, serving as an indicator of your current circulating burden and exposure.
Are microplastics harmful?
Research is ongoing. Scientists are studying how they may contribute to inflammation and long-term health effects.
What is Therapeutic Plasma Exchange (TPE)?
TPE is a well-established medical procedure that gently separates your blood to remove and replace the plasma — the liquid portion that carries proteins and other substances. This process helps clear harmful components that may contribute to inflammation, immune dysfunction, or accelerated aging.
Does insurance cover TPE?
TPE for this use is typically private-pay. Clinics will provide full details during consultation.
What kind of outcomes can be expected?
Patients frequently report measurable improvements in energy, cognitive clarity, and overall vitality. Objective data may include reduced inflammatory biomarkers, improved immune balance, and better metabolic parameters. Early studies suggest potential benefits for supporting healthy aging and extending healthspan through improved biological function.
Additional benefits include:
- Help minimize inflammation to mitigate biological aging
- Boost mental clarity, improve memory, and enhance cognitive function
- Promote heart health and improve circulation
- Assist in the removal of toxins and support the body's natural detoxification process
- Strengthen the immune system to feel well and stay well
- Revitalize and restore overall health and wellness
- Support healthy lipid levels by removing harmful cholesterol
